Professional Education
Dates Attended
Institution Name
City, State Degree/Area of Study
1973-1976 Hubei Medical University P. R. China B.S. Medicine 
1978-1981 Hubei Medical University P. R. China M.D. Cardiology/Physiology
1993-1998 University of TX Health Sci. Ctr San Antonio, TX Ph.D. Molecular biology/Physiology
Research Interests / Specialty

Dr. Zhongmao Guo is a professor in the Department of Physiology at Meharry Medical College. He acquired his M.D. from Hubei Medical University in People’s Republic of China in 1981, and Ph.D. from University of Texas Health Science Center at San Antonio in 1998. He received postdoctoral trainings at Hubei Medical University, Johns Hopkins University, U.S. Army Medical Research Institute of Infectious Diseases, and University of Texas Health Science Center at San Antonio. Dr. Guo joined Meharry Medical College in 2002 as an Associate Professor of physiology, was promoted to Professor in 2006, and appointed as an interim Chair of Department of Cardiovascular Biology in 2008. His research focuses on atherosclerosis and hypertension.

Dr. Zhongmao Guo is a professor in Department of Physiology at Meharry Medical College. His current research focuses on atherosclerosis and hypertension, of which African-Americans show higher prevalence. Dr. Guo’s goal is to understand the molecular mechanisms, especially on signaling pathways that link multiple stresses to atherosclerosis and hypertension, and develop therapeutic strategies that inhibit these signaling pathways in treatment or prevention of cardiovascular diseases. Dr. Guo’s research is currently supported by two grants from the National Institutes of Health. He has published a total of 61 peer-reviewed papers and one patent since 1981.

Dr. Guo’s laboratory studies the mechanisms by which reactive oxygen species regulate vascular functions and contribute to vascular diseases.  This research exploits genome-wide assessment of genes and proteins with gene array and proteomics strategies, as well as cell biological strategies and transgenic/knockout approaches to outline the critical signal transduction pathways in the genesis of atherosclerosis and hypertension.  Dr. Guo's laboratory also collaborates with physicians to study the role of oxidative stress in the disparity of hypertension in African-Americans.

Publications / Scholarly Activities
  • Shi M, Yang H, Motley ED, Guo Z.  Overexpression of Cu/Zn-superoxide dismutase and/or catalase in mice inhibits aorta smooth muscle cell proliferation Am J Hypertens; 17:450-6, 2004.
  • Wu, D.F., H. Yang L.C. Zhou, W. Xiang, M.J. Shi, J.M. LaPlante, B.R. Ballard, and Guo Z.M. Heterozygous mutation at ataxia telangiectasia mutated gene aggravates hypercholesterolemia in mice lacking apolipoprotein E. J. Lipid Res. 46:1380-1387, 2005.
  • Yang, H., L. J. Roberts, M.J. Shi, B.R. Ballard, L.C. Zhou, A. Richardson and Z.M. Guo. Retardation of atherosclerosis by overexpression of catalase or both Cu/Zn-superoxide and catalase in mice lacking apolipoprotein E. Cir. Res. 95:1075-1081, 2004.
  • Yang, H., M.J. Shi, H. VanRemmen, X.L. Chen, J. Vijg, A. Richardson and Z.M. Guo.  Reduction of pressor response to vasoconstrictor agents by overexpression of catalase in mice.  Am. J. Hypert. 16:1-5, 2003.