Aramandla Ramesh, Ph.D.
Assistant Professor
Department of Cancer Biology, Department of Biomedical Sciences
(615) 327-6163
WBS, Room 3210
1005 Dr. D.B. Todd Boulevard
Nashville, TN 37208
aramesh@mmc.edu
Lab URL
CV or Bio (PDF)
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| Professional Education |
| Ph.D. in Marine Microbiology, Annamalai University, India and Ph.D. in Environmental Toxicology, Ehime University, Japan |
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| Research Interests |
The research in Dr. Ramesh’s laboratory focuses on Benzo(a)pyrene (BaP), a lipophilic, widely distributed environmental toxicant that belongs to the polycyclic aromatic hydrocarbon (PAH) family of compounds. Their studies have shown that exposure of rats to BaP and other PAHs cause induction of the cytochrome P450 (CYP) family of enzymes resulting in the formation and distribution of reactive metabolites in plasma and target tissues. Dietary exposure of rats to PAHs via saturated fat results in increased concentration of reactive metabolites, which stay in target tissues for a longer time and cause enhanced DNA damage. Their hypothesis is that dietary fat contributes to BaP-induced colon carcinogenesis through CYP-mediated epoxide and quinone pathways. They are testing their hypothesis by studying the effects of oral exposure of adult Apc Min -/- mice, a colon cancer model, to BaP in saturated fat. Information gained from these studies will reveal the contribution of consumption of fatty foods contaminated with toxic chemicals towards the development of colorectal cancers in humans. |
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| Selected Publications |
Saunders CR, Das SK, Ramesh A, Shockley DC, Mukherjee S. Benzo(a)pyrene-induced acute neurotoxicity in the F-344 rat: role of oxidative stress. J Appl Toxicol. 2006;26:427-38.
Walker SA, Addai AB, Mathis M, Ramesh A. Effect of dietary fat on metabolism and DNA adduct formation after acute oral exposure of F-344 rats to fluoranthene. J Nutr Biochem. 2006
Ramesh A, Knuckles ME. Dose-dependent benzo(a)pyrene [B(a)P]-DNA adduct levels and persistence in F-344 rats following subchronic dietary exposure to B(a)P. Cancer Lett. 2006 Aug ;240:268-78.
Walker SA, Whitten LB, Seals GB, Lee WE, Archibong AE, Ramesh A. Inter-species comparison of liver and small intestinal microsomal metabolism of fluoranthene. Food Chem Toxicol. 2006;44:380-7.
Ramesh A, Inyang F, Knuckles ME. Modulation of adult rat benzo(a)pyrene (BaP) metabolism and DNA adduct formation by neonatal diethylstilbestrol (DES) exposure. Exp Toxicol Pathol. 2004;56:129-38. |
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