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Meharry Medical College - Faculty
School of Medicine Faculty School of Dentistry Faculty School of Graduate Studies and Research Faculty Home

Bogdan Nowicki, M.D. Ph.D.
Professor

Obstetrics and Gynecology

(615) 327-6659
Fax (Fax)
1005 Dr. D.B. Todd Boulevard
Hubbard
4th Floor
Nashville, TN  37208

bnowicki @mmc.edu

CV or Bio (PDF)


 
Professional Education

Medical School of Gdansk, Poland MD 1973 Medicine
Medical School of Gdansk, Poland Intern 1974 Medicine
1st degree 1977 Clinical Microbiology
Medical School of Gdansk, Poland PhD 1980 Microbiology
2nd degree 1982 Clinical Microbiology

 
Research Interests
1R01 HD41687-01 Bogdan Nowicki (Co-PI) 08/1/2005-08/1/2007 NIH CD55, Infection, and Race in Preterm Delivery The major goals of this project are to characterize the expression of DAF among AA and CS women undergoing elective pregnancy termination and term and preterm labor. Role: PI

1R01 HD41687-01 Bogdan Nowicki (PI) 12/1/2001–11/30/2005 NIH CD55, Infection, and Race in Preterm Delivery The major goals of this project are to characterize the expression of DAF among AA and CS women undergoing elective pregnancy termination and term and preterm labor. Role: PI

1R01-HL72650-01 Chandra Yallampalli (PI) 12/01/02–11/30/07 NIH Low Birth Weight, Uterine Infection, and Nitric Oxide The objectives of this grant are to assess if nitric oxide modulates severity of uterine infection through the regulation of bacterial invasion into cells. Role: Co-Investigator

2505-01 Bogdan Nowicki (PI) 2000–2002 UTMB/John Sealy Research Development Award The Interaction of Complement C3 Convertase, and its Sub-Units, with DAF (CD55) The major goals of this project were to characterize the interaction of the classical complement pathway C3 convertase with human DAF (CD55). Role: PI

5R01 DK420209-08 Bogdan Nowicki (PI) 12/01/1996–11/30/2000 NIH Role of Bacterial Lectins in Kidney Disease The major goals of this project were to test the location of Dr receptors in different parts of mouse urinary tract, analyze quantitation of Dr receptor content in studied group and analyze structure function relationship between DAF & Dr adhesion. Role: PI
 
Selected Publications

Kelver ME, Kaul A, Nowicki B, Findley WE, Hutchens TW, Nagamani M. Estrogen Regulation of Lactoferrin Expression in Human Endometrium. Am. J. Reprod. Immunol. (Nov) 1996. 36:243–247.

Goluszko, P, Moseley S, Truong, LD, Kaul A, Nowicki S, Nowicki B. Development of Experimental Model of Chronic Pyelonephritis with Escherichia coli O75:K5:H- bearing Dr Fimbriae: Mutation in the dra Region Prevented Tubulointerstitial Nephritis. J Clin Invest. (Apr) 1997. 99:1–11.

Nowicki, S, Ram, P, Pham, T, Goluszko, P, Morse, S, Anderson, GD, Nowicki B. Pelvic Inflammatory Disease Isolates of Neisseria gonorrhoeae Are Distinguished by C1q-Dependent Virulence for Newborn Rats and by the sac

Region. Infect. Immun. (June) 1997. 65:2094–2099. 4. Goluszko P, Popov V, Selvarangan R, Nowicki S, Pham T, Nowicki B. Dr fimbriae Operon of Uropathogenic Escherichia coli Mediate Microtubule-Dependent Invasion to the HeLa Epithelial Cell Line. J Infect Dis (July) 1997. 176:158-67.

Pham TQ, Goluszko P, Popov V, Nowicki S, Nowicki B. Molecular Cloning and Characterization of Dr-II, a Nonfimbrial Adhesin-Like Adhesin Isolated from Gestational Pyelonephritis-Associated Escherichia coli That Binds to Decay-Accelerating Factor. Infect. Immun. (Oct) 1997. 65(10):4309-4318.

Nowicki B, Fang L, Singhal S, Nowicki S and Yallampalli C. Lethal Outcome of Uterine Infection in Pregnant but Not in Nonpregnant Rats and Increased Death Rate with Inhibition of Nitric Oxide. Am J Reprod. Immun. (Oct) 1997;38:309-312.

B. Nowicki, J. Singhal, L. Fang, S. Nowicki, C. Yalampalli: “Inverse relationship between severity of experimental pyelonephritis and nitric oxide production in C3H/HeJ mice. Infection and Immunity, May 1999 67(5):2421-2427.

Fang L, Nowicki B, Dong YL, Yallampalli C: “Localized increase in nitric oxide production and the expression of nitric oxide isoforms in rat uterus with experimental intrauterine infection” Am J Obstet Gynecol, Sept 1999 18(3):601-609.

Selvarangan R, Goluszko P, Popov V, Singhal J, Pham T, Lublin DM, Nowicki S, and Nowicki B: “Role of Decay-Accelerating Factor domains and anchorage in Internalization of Dr. Fimbriated Escherichia coli” Infect Immun. 2000 68(3);1391-1399.

Nowicki S, Hart A, Nowicki B. Susceptibility to Gonococcal Infection During the Menstrual Cycle JAMA 2000;283(10):1291-1292.

Peiffer I, Guignot J, Barbat A, Carnoy C, Moseley S, Nowicki B, Servin A, Bernet-Camard MF. Structural and functional lesions in brush border of human polarized intestinal Caco-2/TC7 cells infected by members of the Afa/Dr diffusely adhering family of Escherichia coli. Infect Immun 2000,68(10):5979-5990.

Guignot J, Breard J, Bernet-Camard MF, Peiffer I, Nowicki BJ, Servin AL, Blanc-Potard AB. Pyelonephritogenic diffusely adhering Escherichia coli EC7372 harboring Dr-II adhesin carries classical uropathogenic virulence genes and promotes cell lysis and apoptosis in polarized epithelial caco-2/TC7 cells. Infect Immun 2000 68 (12):7018-27.

Fang L, Nowicki B, Yallampalli C. Differential expression of uterine nitric oxide system in pregnant and nonpregnant rats with intrauterine bacterial infection. Am J Physiol. 280:R1363,2001.

Goluszko P, Selvarangan R, Nowicki BJ, Nowicki S, Hart A, Pawelczyk E, Nguyen K. A Rapid Receptor-Clustering Assay to Detect Uropathogenic and Diarrheal Escherichia coli Bearing Adhesins of Dr Family. J Clin Micro 2001 39(6):2317-20.

Goluszko P, Niesel D, Nowicki B, Selvarangan R, Nowicki S, Hart A, Pawelczyk E, Das M Urvil P and Hasan R. Dr operon-associated invasiveness of Escherichia coli from pregnant patients with pyelonephritis. Infect Immun 2001 69(7) 4678-4680.

Le Bouguenec C, Lalioui L, DuMerle L, Jouve M, Courcoux P, Bouzari S, Selvarangan R, Nowicki BJ, Germani Y, Andremont A, Gounon P, and Garcia MI. Characterization of AfaE adhesins produced by extraintestinal and intestinal human Escherichia coli isolates: PCR assays for detection of Afa adhesins that do or do not recognize Dr blood group antigens. J Clin Micro 2001:39(5);1738-1745.

Hart A, Nowicki BJ, Reisner B, Pawelczyk E, Goluszko P, Urvil P, Anderson G, and Nowicki S. Ampicillin-resistant Escherichia coli in gestational pyelonephritis: increased occurrence and association with the colonization factor Dr adhesin. J Infect Dis 2001 May 15;183(10):1526-9.

Nowicki S, Nowicki B, Pham T, Hasan R, Nagamani M. Expression of Decay Accelerating Factor (DAF) in Endometrial Adenocarcinoma is Inversely Related to the Stage of Tumor. Am J Reprod Immun 2001; 46:144-148.

Hasan RJ, Pawelczyk E, Urvil P,* Venkatarajan MS, Goluszko P, Kur J, Selvarangan R, Nowicki S, Braun WA, Nowicki BJ. Structure-Function Analysis of Decay Accelerating Factor. Identification of Residues Important for Binding of Escherichia coli Dr-adhesin and Complement Regulation. Infect Immun 2002 Aug; 70(8): 4485-4493.

Zalewska B, Piatek R, Cieslinski H, Nowicki B, and Kur J. Cloning, expression, and purification of the uropathogenic Escherichia coli invasin DraD. Protein Exp Puri 2001 23:476-82.

Young SL, Lessey BA, Fritz MA, Meyer WR, Murray MJ, Speckman PL, and Nowicki BJ. In Vivo and in Vitro evidence suggest that HB-EGF regulates endometrial expression of human decay-accelerating factor. J Clin Endocrinol Metab 2002 87: 1368-1375.

Johnson JR, Stell AL, O’Bryan TT, Kuskowski M, Nowicki B, Johnson C, Maslow JN, Kaul A, Kavle J and Prats G. Global Molecular Epidemiology of the O15:K52:H1 Extraintestinal Pathogenic Escherichia Coli Clonal Group: Evidence of Distribution Beyond Europe. J Clin Microbiol 2002 40(6):1913-23

Nowicki, B. Urinary Tract Infection in Pregnant Woman : Old Dogmas and Current Concepts Regarding Pathogenesis. Current Infectious Disease Reports. 2002 4 :529-535

Zalewska B, Piatek R, Konopa G, Nowicki B., Nowicki, S., Kur, J. Chimeric Dr. Fimbriae With A Herpes Simplex Virus Type 1 Epitope As A Model For A Recombinant Vaccine. Infection and Immunity 2003 71: 5505-5513