Evangeline D. Motley-Johnson, Ph.D.
Associate Dean of School of Graduate Studies and Research
Professor
Department of Cardiovascular Biology,
Department of Biomedical Sciences

(615) 327-6533
West Basic Sciences Building
1005 Dr. D.B. Todd Boulevard
Nashville, TN  37208

emotley@mmc.edu

Lab URL

CV or Bio (PDF)

University of Virginia, Charlottesville, VA, B.A. in Biology 
Howard University, Washington, D.C., Ph.D. in Physiology and Biophysics
University of Cincinnati, Cincinnati, OH, Postdoctoral Fellow in Cardiovascular Pharmacology

Dr. Motley’s laboratory studies the signal transduction mechanisms responsible for changes in the vasculature that lead to hypertension, atherosclerosis and diabetes.  She and her colleagues have delineated the signaling pathway by which angiotensin II, a known hypertensive agent, causes vascular smooth muscle cell proliferation.  They further demonstrated that angiotensin II and reactive oxygen species are involved in signaling pathways that lead to insulin resistance, is a hallmark of diabetes.  Their current research is focused on the role of thrombin in endothelial dysfunction. 

Suzuki H, Eguchi K, Ohtsu H, Higuchi S, Dhobale S, Frank GD, Motley ED, Eguchi S.  Activation of Endothelial Nitric Oxide Synthase by the Angiotensin II Type-1 Receptor. Endocrinology. 2006

Ohtsu H, Suzuki H, Nakashima H, Dhobale S, Frank GD, Motley ED, Eguchi S.  Angiotensin II signal transduction through small GTP-binding proteins: mechanism and significance in vascular smooth muscle cells. Hypertension. 2006;48:534-40

Suzuki H, Motley ED, Frank GD, Utsunomiya H, Eguchi S.  Recent progress in signal transduction research of the angiotensin II type-1 receptor: protein kinases, vascular dysfunction and structural requirement.  Curr Med Chem Cardiovasc Hematol Agents. 2005; 3:305-22. Review.

Woolfolk EA, Eguchi S, Ohtsu H, Nakashima H, Ueno H, Gerthoffer WT, Motley ED. Angiotensin II-induced activation of p21-activated kinase 1 requires Ca2+ and protein kinase Cγ in vascular smooth muscle cells. Am J Physiol Cell Physiol. 2005; 289:C1286-94.

Frank, G.D., Eguchi, S. and Motley, E.D. The role of reactive oxygen species in insulin signaling in the vasculature.  Antiox. Redox. Signal. 7:  1053-1061, 2005.

Woolfolk, E.A., Eguchi, S, and Motley, E.D.  Angiotensin II-induced activation of p-21 activated kinase requires Ca2+ and PKC-delta in vascular smooth muscle cells.  Am. J. Physiol.  289: C1286-1294, 2005.