Guo-Huang Fan, Ph.D.
Assistant Professor
Department of Neurobiology and Neurotoxicology, Department of Biomedical Sciences

(615) 327-6363
3232 WBS Building
1005 Dr. D.B. Todd Boulevard
Nashville, TN  37221

gfan@mmc.edu

Lab URL

CV or Bio (PDF)

Ph.D.,Shanghai Second Medical University, China, in 1996.

Postdoctoral  training: Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences; Department of Pharmacology at University of Wuerzburg, Germany; Department of Cancer Biology, Vanderbilt University School of Medicine.

Dr. Fan’s lab investigates chemokine receptors, known to play an important role in leukocyte homing in immune responses and recently discovered to be involved in neurodegeneration, cancer growth and metastasis, and HIV infection. Dr. Fan and his colleagues are interested in the role of chemokine receptors in neurodegeneration, including in the development of beta-amyloid-induced dementia (Alzheimer's disease) and HIV-associated dementia.They propose that chemokine receptor-mediated signaling and intracellular trafficking of the receptors are critical for the functional consequences of these receptors in the CNS. They have identified a number of proteins that regulate receptor signaling and trafficking, their goal is to identify their causal roles in neurodegeneration as a first step toward identifying non therapeutic targets for these diseases.

Luo C, Pan H, Mines M, Watson K, Zhang J, Fan GH.  CXCL12 induces tyrosine phosphorylation of cortactin which plays a role in CXCR4-mediated extracellular signal regulated kinase activation and chemotaxis. J Biol Chem. 281:30081-93, 2006;.

Ding Y, Li M, Zhang J, Li N, Xia Z, Hu Y, Wang S, Fan GH.  The 73-kDa heat shock cognate protein is a CXCR4 binding protein that regulates the receptor endocytosis and the receptor-mediated chemotaxis. Mol Pharmacol. 69:1269-79 2006

Neel NF, Schutyser E, Sai J, Fan GH, Richmond A.  Chemokine receptor internalization and intracellular trafficking.  Cytokine Growth Factor Rev 16:637-58, 2005.

Luo Q, Ding Y, Watson K, Zhang J, Fan GH.  N-methyl-D-aspartate attenuates CXCR2-mediated neuroprotection through enhancing the receptor phosphorylation and blocking the receptor recycling.  Mol Pharmacol. 68:528-37. 2005

Watson K, Fan GH. Macrophage inflammatory protein 2 inhibits beta-amyloid peptide (1-42)-mediated hippocampal neuronal apoptosis through activation of mitogen-activated protein kinase and phosphatidylinositol 3-kinase signaling pathways. Mol Pharmacol. 2005, 67:757-765.