Habibeh Khoshbouei, Pharm. D., Ph.D.
Assistant Professor
Department of Neurobiology and Neurotoxicology, Department of Biomedical Sciences

Office: (615) 327-6472
Lab: (615) 321-2948
1005 Dr. D.B. Todd Boulevard
Nashville, TN  37208

hkhoshbouei@mmc.edu

Lab URL

CV or Bio (PDF)

1989 Pharm D., University of Tehran College of Pharmacy, Pharmacy
1995 Pharm D., University of Texas, Neurobiology
2001 Ph.D., University of Texas, Health Science Center, Pharmacology
2002 Post-doctoral, University of Texas,  Health Science Center, Pharmacology
2005 Research Instructor, Vanderbilt University, Molecular Physiology and Biophysics

The long term research goal of Dr. Khoshbouei’s lab is to understand the mechanisms that govern reverse transport of DA by its transporter. Understanding how dopamine transporter molecules change the direction in which they move DA and the significance of such reverse transport in normal physiology is essential for understanding DAT function in the brain.  Her laboratory is investigating molecular and functional aspects of reverse transport in heterologous systems engineered to express DAT and in transgenic mice whose DA neurons are fluorescently tagged.  She utilizes a multidisciplinary approach by combining diverse techniques, including  whole-cell patch clamp and amperometry recordings, confocal and wide field microscopy, biochemical methods and behavioral analysis to identify novel cellular and molecular modulators of DAT activity that can be targeted for treatment of drug addiction, mood disorders or other DA related pathologies, such as Parkinson’s disease and schizophrenia.

Fog JU, Khoshbouei H, Holy M, Owens WA, Vaegter CB, Sen N, Nikandrova Y, Bowton E, McMahon DG, Colbran RJ, Daws LC, Sitte HH, Javitch JA, Galli A, Gether U.  Calmodulin kinase II interacts with the dopamine transporter C terminus to regulate amphetamine-induced reverse transport.  Neuron. 2006;51:417-29.

Kahlig KM, Binda F, Khoshbouei H, Blakely RD, McMahon DG, Javitch JA, Galli A.   Amphetamine induces dopamine efflux through a dopamine transporter channel. Proc Natl Acad Sci U S A. 2005;102:3495-500.

Gnegy ME, Khoshbouei H, Berg KA, Javitch JA, Clarke WP, Zhang M, Galli A.  Intracellular Ca2+ regulates amphetamine-induced dopamine efflux and currents mediated by the human dopamine transporter. Mol Pharmacol. 2004;66:137-43.

Khoshbouei H, Sen N, Guptaroy B, Johnson L, Lund D, Gnegy ME, Galli A, Javitch JA.  N-terminal phosphorylation of the dopamine transporter is required foramphetamine-induced efflux.  PLoS Biol. 2004;2:E78.

Morilak DA, Cecchi M, Khoshbouei H.  Interactions of norepinephrine and galanin in the central amygdala and lateral bed nucleus of the stria terminalis modulate the behavioral response to acute stress.  Life Sci. 2003 ;73:715-26. Review.