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Name

Hua Xie, D.D.S., Ph.D.
Associate Professor

Department of Stomatology School of Dentistry

(615) 327-5981
1005 Dr. D.B. Todd Boulevard
Nashville, TN 37208

hxie@mmc.edu

CV or Bio (PDF)

Professional Education

Research Interests

Is a member of the faculty of both the School of Dentistry and the School of Medicine whose research focuses on the molecular bases of oral health and disease. Two major oral infectious diseases, caries and periodontitis, are dental plaque (biofilm)-associated diseases. Dental plaque is a multispecies biofilm, and over 30 genera representing more than 500 species of bacteria have been found in this ecological environment. Despite this complexity, plaque formation is highly choreographed, beginning with initial colonization by a group of gram-positive aerobic bacteria, predominantly Streptococcus and Actinomyces, followed by a succession of gram-negative anaerobic bacteria. Although dental plaque can be detected on tooth surfaces in every oral cavity, it does not always lead to periodontal diseases. The transition from a commensal .bacterial accumulation to periodontopathonic plaque involves the colonization of certain species of gram-negative anaerobic bacteria onto dental plaque, such as Porphyromonas gingivalis in the case of adult periodontitis. The long range goal of Dr. Xie’s research is to gain a molecular understanding of events leading to the transformation of healthy plaque to pathogenic plaque and to change the course of development of pathogenic biofilm by preventing attachment of P. gingivalis. She is using both gene array and proteomics tools to address the question of how communication is established between P. gingivalis and the primary colonizers of the dental biofilm, particularly Streptococcus cristatus and what are the mechanisms by which P. gingivalis is excluded from dental plaques by S. cristatus. A principal hypothesis that Streptococcus cristatus plays an important role in impeding Porphyromonas gingivalis’ colonization on dental biofilm through inter-generic signaling systems.

Selected Publications

Yu S, Wu L, Jin J, Yan S, Jiang G, Xie H, Zheng S. Influence of CYP3A5 Gene Polymorphisms of Donor Rather than Recipient to Tacrolimus Individual Dose Requirement in Liver Transplantation. Transplantation. 2006 Jan 15;81(1):46-51.
Wang H, Xie H, Zhang H, Das SK, Dey SK. Conditional gene recombination by adenovirus-driven Cre in the mouse uterus. Genesis. 2006 Jan 13;44(2):51-56 [Epub ahead of print]

Shao F, Wang G, Sun J, Xie H, Li H, Liang Y, Zhang R, Zhu X. Liquid chromatographic/mass spectrometry assay of triptolide in dog plasma and its application to pharmacokinetic study. J Pharm Biomed Anal. 2005 Dec 31; [Epub ahead of print]

Lou T, Xie H, Chen G, Gagne JP. Effects of photodegradation of dissolved organic matter on the binding of benzo(a)pyrene. Chemosphere. 2006 Jan 5; [Epub ahead of print]

Luo XH, Guo LJ, Shan PF, Xie H, Wu XP, Zhang H, Cao XZ, Yuan LQ, Liao EY. Relationship of circulating MMP-2, MMP-1, and TIMP-1 levels with bone biochemical markers and bone mineral density in postmenopausal Chinese women. Osteoporos Int. 2005 Dec 20;:1-6 [Epub ahead of print]

Chen Y, Ji F, Xie H, Liang J, Zhang J. The regulator of g-protein signaling proteins involved in sugar and abscisic Acid signaling in Arabidopsis seed germination. Plant Physiol. 2006 Jan;140(1):302-10. Epub 2005 Dec 16.

Ye JY, Luo GY, Wang TJ, Chen HL, Xie H. [Preliminary study on bacterial culture through near-natural pure culture technique] Wei Sheng Wu Xue Bao. 2005 Oct;45(5):802-4. Chinese.

Xie H, Huang Z, Sadim MS, Sun Z. Stabilized beta-catenin extends thymocyte survival by up-regulating Bcl-xL. J Immunol. 2005 Dec 15;175(12):7981-8.

Wang J, Wu K, Bai F, Zhai H, Xie H, Du Y, Liang J, Han S, Chen Y, Lin T, Fan D. Celecoxib could reverse the hypoxia-induced Angiopoietin-2 upregulation in gastric cancer. Cancer Lett. 2005 Dec 6; [Epub ahead of print]

Shan PF, Wu XP, Zhang H, Luo XH, Cao XZ, Xie H, Liu SP, Pi YZ, Fang TY, Liu H, Chen ZH, Zhong N, Liao EY. Age-related changes of serum bone alkaline phosphatase and cross-linked C-telopeptides of type I collagen and the relationship with bone mineral density in Chinese women. Clin Chim Acta. 2005 Dec 1; [Epub ahead of print]

Yuan J, Wu XJ, Lu WQ, Cheng XL, Chen D, Li XY, Liu AL, Wu JJ, Xie H, Stahl T, Mersch-Sundermann V. Chlorinated river and lake water extract caused oxidative damage, DNA migration and cytotoxicity in human cells. Int J Hyg Environ Health. 2005;208(6):481-8. Epub 2005 Oct 10.

Wang R, Wang G, Hao H, Xie H, Zhang J, Wu F. Quantitative determination of atractylenolide III in rat plasma by liquid chromatography electrospray ionization mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Nov 29; [Epub ahead of print]

Bartels SJ, Miles KM, Van Citters AD, Forester BP, Cohen MJ, Xie H. Improving mental health assessment and service planning practices for older adults: a controlled comparison study. Ment Health Serv Res. 2005 Dec;7(4):213-23.

Wei JF, Mo YZ, Qiao LY, Wei XL, Chen HQ, Xie H, Fu YL, Wang WY, Xiong YL, He SH. Potent histamine-releasing activity of atrahagin, a novel snake venom metalloproteinase. Int J Biochem Cell Biol. 2005 Nov 9; [Epub ahead of print]

Huang C, Wang G, Li H, Xie H, Sun J, Lv H, Lv T. Sensitive and selective liquid chromatography-electrospray ionisation-mass spectrometry analysis of astragaloside-IV in rat plasma. J Pharm Biomed Anal. 2005 Nov 21; [Epub ahead of print]
Xie H, Sui Y, Chang FQ, Xu Y, Ma RC. SSR allelic variation in almond (Prunus dulcis Mill.). Theor Appl Genet. 2006 Jan;112(2):366-72. Epub 2005 Nov 24.

Dong ZQ, Wang YQ, Ma F, Xie H, Wu GC. Down-regulation of GFRalpha-1 expression by antisense oligodeoxynucleotide aggravates thermal hyperalgesia in a rat model of neuropathic pain. Neuropharmacology. 2005 Nov 11; [Epub ahead of print]

Wise SS, Holmes AL, Moreland JA, Xie H, Sandwick SJ, Stackpole MM, Fomchenko E, Teufack S, May AJ Jr, Katsfis SP, Wise JP Sr. Human lung cell growth is not stimulated by lead ions after lead chromate-induced genotoxicity. Mol Cell Biochem. 2005 Nov;279(1-2):75-84.

Xie H, Heitjan DF. Sensitivity analysis of causal inference in a clinical trial subject to crossover. Clin Trials. 2004 Feb;1(1):21-30. Erratum in: Clin Trials. 2004;1(5):2 p following 474. Clin Trials. 2005;2(2):194.

Chen X, Yang Z, Xie H, Li S. [Biological effect of WO-1 on human embryonic osteoblasts] Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2005 Oct;19(10):822-5. Chinese.