Raju Ramasamy, PhD
Professor
Department of Microbial Pathogenesis & Immune Response
Department of Biomedical Sciences
615-327-6687
West Basic Sciences Building, Rm. 4126
1005 Dr. D.B. Todd Boulevard
Nashville, TN 37208
rramasamy@mmc.edu
Lab URL
CV or Bio (PDF)
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| Professional Education |
Ph.D., Molecular Biology, Indian Institute of Science
Postdoc, Molecular Virology, University of Geneva, School of Medicine
Postdoc, Molecular Virology, Washington University, School of Medicine |
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| Research Interests |
| The research in Dr. Ramasamy’s laboratory focuses on the regulation of RNA dependent RNA synthesis in two mosquito-transmitted RNA viruses namely Sindbis virus and La crosse virus. The RNA genomes of these viruses are engineered to generate defined mutants in vitro and in vivo to address the role of cis and trans-acting functions of viral genome in RNA synthesis, repair and recombination. The long-term stability of engineered RNA viruses and their evolution in mammalian and mosquito cells are studied to understand how viral and host factors regulate viral RNA synthesis. These studies are useful in the development of vaccines and viral vectors. |
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| Selected Publications |
R. Raju. RNA motifs that regulate animal RNA alphavirus synthesis. 2003. In mechanisms of Replication and Transcription of RNA viruses 81, 77-92. Ed. Xuming Xhang. Research signpost. Fort P.O. Trivandrum 695023, Kerala
Wielgosz MM, Raju R, Huang HV. Sequence requirements for Sindbis virus subgenomic mRNA promoter function in cultured cells. J Virol. 2001;75:3509-19.
George J, Raju R. Alphavirus RNA genome repair and evolution: molecular characterization of infectious sindbis virus isolates lacking a known conserved motif at the 3' end of the genome. J Virol. 2000 ;74:9776-85. |
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