1975 B.S., University of Science & Technology, Ghana, Biochemistry
1980 M.S., University of British Columbia, Canada, Pharmacology
1983 Ph.D., University of British Columbia, Canada, Pharmacology
1983-1987 Postdoctoral Physiology, University of Manchester, England |
The research in Dr. Ansah’s laboratory seeks to understand the neurobiological mechanisms that mediate psychiatric disorders such as depression and drug abuse as well as neurological disorders, such as Parkinson’s, all of which involve the dopaminergic system and its regulation by other systems, such as the serotonergic system. His major research efforts are being devoted to systematically investigate alterations in the 5-HT system and to understand its role in the hypokinesia produced by lesioning of the dopaminergic system with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). The objective is to understand the role of 5-HT in the neurobiology of Parkinson’s Disease and how manipulating the 5-HT system might alter the course of the disease, as a preclude to identification of novel therapeutic targets for the disease. |
Ansah TA, Ramamoorthy S, Montanez S, Daws LC, Blakely RD. Calcium-dependent inhibition of synaptosomal serotonin transport by the alpha 2-adrenoceptor agonist 5-bromo-N-[4,5-dihydro-1H-imidazol-2-yl]-6-quinoxalinamine (UK14304). J Pharmacol Exp Ther. 2003;305:956-65.
Ansah TA, Wade LH, Kopsombut P, Shockley DC. Nifedipine potentiates the toxic effects of cocaine in mice. Prog Neuropsychopharmacol Biol Psychiatry. 2002;26:357-62.
Mills, K., Ansah, T.-A., Ali, S.F. and Shockley, D.C. Calcium channel antagonist isradipine attenuates cocaine-induced motor activity in rats: Correlation with brain monoamine levels. Ann. N.Y. Acad. Sci. 844: 201-207, 1998.
Ansah TA, Wade LH, Shockley DC. Changes in locomotor activity, core temperature, and heart rate in response to repeated cocaine administration. Physiol Behav., 60, 1261-1267, 1996
Ansah TA, Wade LH, Shockley DC . Effects of calcium channel entry blockers on cocaine and amphetamine-induced motor activities and toxicities. Life Sci. , 53, 1947-1956, 1993 |
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