Waldemar Popik, Ph.D.
Associate Professor

Internal Medicine

(615) 327-6734
Fax (Fax)
1005 Dr. D.B. Todd Boulevard
WBS
Room # 4012A
Nashville, TN  37208

wpopik@mmc.edu

CV or Bio (PDF)

1977 M.S. University of Wroclaw, Poland, Physics and Chemistry
1981 M.S. University of Wroclaw, Poland, Biochemistry The Faculty of Biological Sciences, Department of Biochemistry
1987 Ph.D. Ludwik Hirszfeld Institute of Biochemistry Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, Poland

Molecular mechanisms controlling integrity and assembly of lipid rafts and their role in HIV entry into CD4-positive T cells. Development of exosomes with encapsidated APOBEC3G as potential anti-HIV therapeutics.

Fiala M, Eshleman AJ, Cashman J, Lin J, Lossinsky AS, Suarez V, Yang W, Zhang J, Popik W, Singer E, Chiappelli F, Carro E, Weinand M, Witte M, Arthos J. Cocaine increases human immunodeficiency virus type 1 neuroinvasion through remodeling brain microvascular endothelial cells. J Neurovirol. 2005 Jul;11(3):281-91.

Fiala M, Popik W, Qiao JH, Lossinsky AS, Alce T, Tran K, Yang W, Roos KP, Arthos J. HIV-1 induces cardiomyopathyby cardiomyocyte invasion and gp120, Tat, and cytokine apoptotic signaling. Cardiovasc Toxicol. 2004;4(2):97-107.

Alce TM, Popik W. APOBEC3G is incorporated into virus-like particles by a direct interaction with HIV-1 Gag nucleocapsid protein. J Biol Chem. 2004 Aug 13;279(33):34083-6. Epub 2004 Jun 23.

Popik W, Alce TM. CD4 receptor localized to non-raft membrane microdomains supports HIV-1 entry. Identification of a novel raft localization marker in CD4. J Biol Chem. 2004 Jan 2;279(1):704-12. Epub 2003 Oct 21.

Twu C, Liu NQ, Popik W, Bukrinsky M, Sayre J, Roberts J, Rania S, Bramhandam V, Roos KP, MacLellan WR, Fiala M. Cardiomyocytes undergo apoptosis in human immunodeficiency virus cardiomyopathy through mitochondrion- and death receptor-controlled pathways. Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):14386-91. Epub 2002 Oct 11.

Liu NQ, Lossinsky AS, Popik W, Li X, Gujuluva C, Kriederman B, Roberts J, Pushkarsky T, Bukrinsky M, Witte M, Weinand M, Fiala M. Human immunodeficiency virus type 1 enters brain microvascular endothelia by macropinocytosis dependent on lipid rafts and the mitogen-activated protein kinase signaling pathway. J Virol. 2002 Jul;76(13):6689-700.

Popik W, Alce TM, Au WC. Human immunodeficiency virus type 1 uses lipid raft-colocalized CD4 and chemokine receptors for productive entry into CD4(+) T cells. J Virol. 2002 May;76(10):4709-22.

Gujuluva C, Burns AR, Pushkarsky T, Popik W, Berger O, Bukrinsky M, Graves MC, Fiala M. HIV-1 penetrates coronary artery endothelial cells by transcytosis. Mol Med. 2001 Mar;7(3):169-76. Popik W, Pitha PM. Exploitation of cellular signaling by HIV-1: unwelcome guests with master keys that signal their entry. Virology. 2000 Oct 10;276(1):1-6.

Popik W, Pitha PM. Inhibition of CD3/CD28-mediated activation of the MEK/ERK signaling pathway represses replication of X4 but not R5 human immunodeficiency virus type 1 in peripheral blood CD4(+) T lymphocytes. J Virol. 2000 Mar;74(6):2558-66.

Popik W, Pitha PM. Early activation of mitogen-activated protein kinase kinase, extracellular signal-regulated kinase, p38 mitogen-activated protein kinase, and c-Jun N-terminal kinase in response to binding of simian immunodeficiency virus to Jurkat T cells expressing CCR5 receptor. Virology. 1998 Dec 5;252(1):210-7.

Popik W, Hesselgesser JE, Pitha PM. Binding of human immunodeficiency virus type 1 to CD4 and CXCR4 receptors differentially regulates expression of inflammatory genes and activates the MEK/ERK signaling pathway. J Virol. 1998 Aug;72(8):6406-13.

Popik W, Pitha PM. Binding of human immunodeficiency virus type 1 to CD4 induces association of Lck and Raf-1 and activates Raf-1 by a Ras-independent pathway. Mol Cell Biol. 1996 Nov;16(11):6532-41.

Su Y, Popik W, Pitha PM. Inhibition of human immunodeficiency virus type 1 replication by a Tat-activated, transduced interferon gene: targeted expression to human immunodeficiency virus type 1-infected cells. J Virol. 1995 Jan;69(1):110-

Shirazi Y, Popik W, Pitha PM. Modulation of interferon-mediated inhibition of human immunodeficiency virus type 1 by Tat. J Interferon Res. 1994 Oct;14(5):259-63.

Zhong F, Swendeman SL, Popik W, Pitha PM, Sheffery M. Evidence that levels of the dimeric cellular transcription factor CP2 play little role in the activation of the HIV-1 long terminal repeat in vivo or following superinfection with herpes simplex virus type 1. J Biol Chem. 1994 Aug 19;269(33):21269-76.

Popik W, Pitha PM. Differential effect of tumor necrosis factor-alpha and herpes simplex virus type 1 on the Tat-targeted inhibition of human immunodeficiency virus type 1 replication. Virology. 1994 Aug 1;202(2):521-9.

Popik W, Pitha PM. The presence of tat protein or tumor necrosis factor alpha is critical for herpes simplex virus type 1-induced expression of human immunodeficiency virus type 1. J Virol. 1994 Mar;68(3):1324-33.

Popik W, Pitha PM. Role of tumor necrosis factor alpha in activation and replication of the tat-defective human immunodeficiency virus type 1. J Virol. 1993 Feb;67(2):1094-9.

Popik W, Pitha PM. Transcriptional activation of the tat-defective human immunodeficiency virus type-1 provirus: effect of interferon. Virology. 1992 Aug;189(2):435-47.