ZhongMao Guo, Ph.D. M.D.
Professor
Department of Cardiovascular Biology, Department of Biomedical Sciences
(615) 327-6804
WBS, Room 3132
1005 Dr. D.B. Todd Boulevard
Nashville, TN 37208
zguo@mmc.edu
Lab URL
CV or Bio (PDF)
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| Professional Education |
1973 - 1976 Hubei Medical University, P. R. China. B.S. Medicine
1978 - 1981 Hubei Medical University, P. R. China. M.D. Cardiology/Physiology
1993 - 1998 University of TX Health Sci. Ctr at San Antonio. Ph.D. Molecular biology/Physiology |
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| Research Interests |
Dr. Guo’s laboratory studies the mechanisms by which reactive oxygen species regulate vascular functions and contribute to vascular diseases. This research exploits genome-wide assessment of genes and proteins with gene array and proteomics strategies, as well as cell biological strategies and transgenic/knockout approaches to outline the critical signal transduction pathways in the genesis of atherosclerosis and hypertension. Dr. Guo's laboratory also collaborates with physicians to study the role of oxidative stress in the disparity of hypertension in African-Americans. |
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| Selected Publications |
Zhou L, Shi M, Guo Z, Brisbon W, Hoover R, Yang H. Different cytotoxic injuries induced by lysophosphatidylcholine and 7-ketocholesterol in mouse endothelial cells. Endothelium. 2006; 13:213-26.
Shi M, Yang H, Motley ED, Guo Z. Overexpression of Cu/Zn-superoxide dismutase and/or catalase in mice inhibits aorta smooth muscle cell proliferation.
Am J Hypertens; 17:450-6, 2004
Wu, D.F., H. Yang L.C. Zhou, W. Xiang, M.J. Shi, J.M. LaPlante, B.R. Ballard, and Guo Z.M. Heterozygous mutation at ataxia telangiectasia mutated gene aggravates hypercholesterolemia in mice lacking apolipoprotein E. J. Lipid Res. 46:1380-1387, 2005.
Yang, H., L. J. Roberts, M.J. Shi, B.R. Ballard, L.C. Zhou, A. Richardson and Z.M. Guo. Retardation of atherosclerosis by overexpression of catalase or both Cu/Zn-superoxide and catalase in mice lacking apolipoprotein E. Cir. Res. 95:1075-1081, 2004.
Yang, H., M.J. Shi, H. VanRemmen, X.L. Chen, J. Vijg, A. Richardson and Z.M. Guo. Reduction of pressor response to vasoconstrictor agents by overexpression of catalase in mice. Am. J. Hypert. 16:1-5, 2003. |
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