RESEARCH CAPABILITIES AT MEHARRY MEDICAL COLLEGE

Bioinformatics

Scientific patternThe Meharry Microarray and Bioinformatics Core (MBC) and The Meharry Proteomics Core (MPC) provide state of the art training, instrumentation, services and bioinformatics-driven data analysis to the Meharry Community in Transcriptomics and Proteomics experimental design, all the way through to advanced data analysis and integration of large scale “Omics” data sets for biomedical research and discovery. These Core Resources provide Meharry investigators and trainees with the tools and expertise needed for high performance computation in Genomics, Proteomics, Systems Biology and Biological Network Analysis. It is our aim to keep this facility up to date computationally and intellectually with state of the art “Omics” services to support education and research in microarray, genomics and proteomics data analysis, computational biology and systems biology.

PAST PERFORMANCE

Research accomplishments within the school have been funded by federal agencies such as Health Resources & Services Administration (HRSA), National Cancer Institute (NCI), National Institute on Minority Health and Health Disparities (NIMHD), National Institute of Allergy and Infectious Diseases (NIAID), Centers for Disease Control (CDC), Nuclear Regulatory Commission (NRC), National Science Foundation (NSF), Department of Education, National Center Minority Health/Health Disparities (NCMHD), National Human Genome Research Institute (NHGRI). State funding at Meharry includes Tennessee Department of Health (TDH). Foundation and Industry funding includes Fuji Oil Company, American Society for Cell Biology, Das, Gilead Sciences, Inc., Astellas Pharma US, Inc., Pfizer Inc., Merck Sharp & Dohme Corp., Genetech, Inc., Bayer AG, United Way of Metropolitan Nashville, Ford Foundation, Lakewood-Amedex, Inc., Patient Advocate Foundation, American Heart Association, and the Peter F. McManus Charitable Foundation among others.
 

SPECIALIZED SOFTWARE

CLC Genomics Workbench 8.0 for Next-generation sequencing (NGS) analysis including Whole Genome Sequencing and RNA-Seq assembly and analysis

Partek Genomics Suite version 6.x for Gene Expression microarray, RNA-Seq and miRNA analysis

PEAKS Proteomics Software version 8.0 for Protein Database search, quantitative proteomics profiling and post-translational modification identification

MATLAB statistical programming environment with bioinformatics, statistics and proteomics analysis

FileMaker Pro for database prototyping

TABLEAU version 9.0 for visual analytics and big data applications

Open Source Bioinformatics / Analytics program expertise:

CYTOSCAPE Systems Biology Tool Kit for visualizations and biological interactions level visualizations in order to frame Omics data results into a biological context.

R statistical packages including Bioconductor for Transcriptomics / Genomics level analysis and visualizations.

REDCap database domain knowledge and training