Publications resulting from Meharry Clinical and Translational Research Center (MeTRC) Grants are listed below.

1: Pandhare J, Addai AB, Mantri CK, Hager C, Smith RM, Barnett L, Villalta F, Kalams SA, Dash C. Cocaine Enhances HIV-1-Induced CD4(+) T-Cell Apoptosis: Implications in Disease Progression in Cocaine-Abusing HIV-1 Patients. Am J Pathol. 2014 Apr;184(4):927-36. doi: 10.1016/j.ajpath.2013.12.004. Epub 2014 Jan 31. PubMed PMID: 24486327; PubMed Central PMCID: PMC3970001.

2: Mantri CK, Mantri JV, Pandhare J, Dash C. Methamphetamine inhibits HIV-1 replication in CD4+ T cells by modulating anti-HIV-1 miRNA expression. Am J Pathol. 2014 Jan;184(1):92-100. doi: 10.1016/j.ajpath.2013.09.011. Epub 2013 Oct 26. PubMed PMID: 24434277; PubMed Central PMCID: PMC3873480.

3: Schramm PJ, Poland RE, Rao U. Bupropion response on sleep quality in patients with depression: implications for increased cardiovascular disease risk. Eur Neuropsychopharmacol. 2014 Feb;24(2):207-14. doi: 10.1016/j.euroneuro.2013.09.007. Epub 2013 Oct 11. PubMed PMID: 24239431; PubMed Central PMCID: PMC3948318.

4: Morris MC, Rao U. Cortisol response to psychosocial stress during a depressive episode and remission. Stress. 2014 Jan;17(1):51-8. doi: 10.3109/10253890.2013.857398. Epub 2013 Nov 20. PubMed PMID: 24144001; PubMed Central PMCID: PMC3920542.

5: Rao U. Biomarkers in pediatric depression. Depress Anxiety. 201 Sep;30(9):787-91. doi: 10.1002/da.22171. Epub 2013 Aug 22. Review. PubMed PMID:24002798; PubMed Central PMCID: PMC3789128.

6: Smith JC, Schäffer MW, Ballard BR, Smoot DT, Herline AJ, Adunyah SE, M'koma AE. Adenocarcinomas After Prophylactic Surgery For Familial Adenomatous Polyposis. J Cancer Ther. 2013;4(1):260-270. PubMed PMID: 23875116; PubMed Central PMCID: PMC3713706.

7: Thota C, Menon R, Fortunato SJ, Brou L, Lee JE, Al-Hendy A.1,25-Dihydroxyvitamin D deficiency is associated with preterm birth in African American and caucasian women. Reprod Sci. 2014 Feb;21(2):244-50. doi:10.1177/1933719113493513. Epub 2013 Jun 21. PubMed PMID: 23793474; PubMed Central PMCID: PMC3879992.

8: Pratap S, Brown LE, Izban MG, Nowicki S, Nowicki BJ. Accurate preterm labor diagnosis using a CD55-TLR4 combination biomarker model. J Biomed Sci Eng. 2013 Mar;6:253-257. PubMed PMID: 23667715; PubMed Central PMCID: PMC3649766.

9: Samet A, Sledzińska A, Krawczyk B, Hellmann A, Nowicki S, Kur J, Nowicki B. Leukemia and risk of recurrent Escherichia coli bacteremia: genotyping implicates E. coli translocation from the colon to the bloodstream. Eur J Clin Microbiol Infect Dis. 2013 Nov;32(11):1393-400. doi:10.1007/s10096-013-1886-9. Epub 2013 May 7. PubMed PMID: 23649557; PubMed Central PMCID: PMC3824565.

10: Morris MC, Rao U, Wang L, Garber J. Cortisol reactivity to experimentally manipulated psychosocial stress in young adults at varied risk for depression. Depress Anxiety. 2014 Jan;31(1):44-52. doi: 10.1002/da.22125. Epub 2013 Apr 19. PubMed PMID: 23606237; PubMed Central PMCID: PMC3735776.

11: Lin X, Yang H, Zhang H, Zhou L, Guo Z. A novel transcription mechanism activated by ethanol: induction of Slc7a11 gene expression via inhibition of the DNA-binding activity of transcriptional repressor octamer-binding transcription factor 1 (OCT-1). J Biol Chem. 2013 May 24;288(21):14815-23. doi:10.1074/jbc.M113.466565. Epub 2013 Apr 16. PubMed PMID: 23592778; PubMed Central PMCID: PMC3663505.

12: Malloy MT, McIntosh DJ, Walters TS, Flores A, Goodwin JS, Arinze IJ. Trafficking of the transcription factor Nrf2 to promyelocytic leukemia-nuclear bodies: implications for degradation of NRF2 in the nucleus. J Biol Chem. 2013 May 17;288(20):14569-83. doi: 10.1074/jbc.M112.437392. Epub 2013 Mar 29. PubMed PMID: 23543742; PubMed Central PMCID: PMC3656310.

13: Nowicki B, Nowicki S. DAF as a therapeutic target for steroid hormones: implications for host-pathogen interactions. Adv Exp Med Biol. 2013;735:83-96. Review. PubMed PMID: 23402020.

14: Seeley EH, Washington MK, Caprioli RM, M'Koma AE. Proteomic patterns of colonic mucosal tissues delineate Crohn's colitis and ulcerative colitis. Proteomics Clin Appl. 2013 Aug;7(7-8):541-9. doi: 10.1002/prca.201200107. Epub 2013 May 8. PubMed PMID: 23382084; PubMed Central PMCID: PMC3737405.

15: Morris MC, Rao U. Psychobiology of PTSD in the acute aftermath of trauma: Integrating research on coping, HPA function and sympathetic nervous system activity. Asian J Psychiatr. 2013 Feb;6(1):3-21. doi: 10.1016/j.ajp.2012.07.012. Epub 2012 Sep 6. Review. PubMed PMID: 23380312; PubMed Central PMCID: PMC3565157.

16: Villalta F, Dobish MC, Nde PN, Kleshchenko YY, Hargrove TY, Johnson CA, Waterman MR, Johnston JN, Lepesheva GI. VNI cures acute and chronic experimental Chagas disease. J Infect Dis. 2013 Aug 1;208(3):504-11. doi:10.1093/infdis/jit042. Epub 2013 Jan 31. PubMed PMID: 23372180; PubMed Central PMCID: PMC3698996.

17: Pellom ST Jr, Shanker A. Development of Proteasome Inhibitors as Therapeutic Drugs. J Clin Cell Immunol. 2012 Mar 15;S5:5. PubMed PMID: 23338480; PubMed Central PMCID: PMC3546515.

18: Timmons CL, Shao Q, Wang C, Liu L, Liu H, Dong X, Liu B. GB virus type C E2 protein inhibits human immunodeficiency virus type 1 assembly through interference with HIV-1 gag plasma membrane targeting. J Infect Dis. 2013 Apr;207(7):1171-80. doi: 10.1093/infdis/jit001. Epub 2013 Jan 9. PubMed PMID: 23303812; PubMed Central PMCID: PMC3583272.

19: Son DS, Kabir SM, Dong YL, Lee E, Adunyah SE. Inhibitory effect of tumor suppressor p53 on proinflammatory chemokine expression in ovarian cancer cells by reducing proteasomal degradation of IκB. PLoS One. 2012;7(12):e51116. doi:10.1371/journal.pone.0051116. Epub 2012 Dec 31. PubMed PMID: 23300534; PubMed Central PMCID: PMC3534106.

20: Gangula PR, Dong YL, Al-Hendy A, Richard-Davis G, Montgomery-Rice V, Haddad G, Millis R, Nicholas SB, Moseberry D. Protective cardiovascular and renal actions of vitamin D and estrogen. Front Biosci (Schol Ed). 2013 Jan 1;5:134-48. Review. PubMed PMID: 23277041; PubMed Central PMCID: PMC3673780.

21: Mantri CK, Pandhare Dash J, Mantri JV, Dash CC. Cocaine enhances HIV-1 replication in CD4+ T cells by down-regulating MiR-125b. PLoS One. 2012;7(12):e51387. doi:10.1371/journal.pone.0051387. Epub 2012 Dec 12. PubMed PMID: 23251514; PubMed Central PMCID: PMC3520918.

22: Duncan MR, Fullerton M, Chaudhuri M. Tim50 in Trypanosoma brucei possesses a dual specificity phosphatase activity and is critical for mitochondrial protein import. J Biol Chem. 2013 Feb 1;288(5):3184-97. doi: 10.1074/jbc.M112.436378. Epub 2012 Dec 4. PubMed PMID: 23212919; PubMed Central PMCID: PMC3561540.

23: Izban MG, Nowicki BJ, Nowicki S. 1,25-Dihydroxyvitamin D3 promotes a sustained LPS-induced NF-κB-dependent expression of CD55 in human monocytic THP-1 cells. PLoS One. 2012;7(11):e49318. doi: 10.1371/journal.pone.0049318. Epub 2012 Nov 12. PubMed PMID: 23152895; PubMed Central PMCID: PMC3495912.

24: Nde PN, Lima MF, Johnson CA, Pratap S, Villalta F. Regulation and use of the extracellular matrix by Trypanosoma cruzi during early infection. Front Immunol. 2012 Nov 6;3:337. doi:10.3389/fimmu.2012.00337. eCollection 2012. PubMed PMID:23133440; PubMed Central PMCID: PMC3490126.

25: Poland RE, Gertsik L, Favreau JT, Smith SI, Mirocha JM, Rao U, Daar ES. Open-label, randomized, parallel-group controlled clinical trial of massage for treatment of depression in HIV-infected subjects. J Altern Complement Med. 2013 Apr;19(4):334-40. doi: 10.1089/acm.2012.0058. Epub 2012 Oct 25. PubMed PMID:23098696; PubMed Central PMCID: PMC3627430.

26: Watson K, Koumangoye R, Thompson P, Sakwe AM, Patel T, Pratap S, Ochieng J. Fetuin-A triggers the secretion of a novel set of exosomes in detached tumor cells that mediate their adhesion and spreading. FEBS Lett. 2012 Sep 21;586(19):3458-63. doi: 10.1016/j.febslet.2012.07.071. Epub 2012 Aug 8. PubMed PMID: 22980907; PubMed Central PMCID: PMC3455109.

27: Liu L, Sutton J, Woodruff E, Villalta F, Spearman P, Dong X. Defective HIV-1 particle assembly in AP-3-deficient cells derived from patients with Hermansky-Pudlak syndrome type 2. J Virol. 2012 Oct;86(20):11242-53. Epub 2012 Aug 8. PubMed PMID: 22875976; PubMed Central PMCID: PMC3457180.

28: Morris MC, Rao U, Garber J. Cortisol responses to psychosocial stress predict depression trajectories: social-evaluative threat and prior depressive episodes as moderators. J Affect Disord. 2012 Dec 20;143(1-3):223-30. doi:10.1016/j.jad.2012.05.059. Epub 2012 Aug 1. PubMed PMID: 22858210; PubMed Central PMCID: PMC3489962.

29: Huang H, Gundapuneedi T, Rao U. White matter disruptions in adolescents exposed to childhood maltreatment and vulnerability to psychopathology. Neuropsychopharmacology. 2012 Nov;37(12):2693-701. doi: 10.1038/npp.2012.133. Epub 2012 Aug 1. PubMed PMID: 22850736; PubMed Central PMCID: PMC3473335.

30: Nair GR, Dash C, Le Grice SF, DeStefano JJ. Viral reverse transcriptases show selective high affinity binding to DNA-DNA primer-templates that resemble the polypurine tract. PLoS One. 2012;7(7):e41712. doi: 10.1371/journal.pone.0041712. Epub 2012 Jul 27. PubMed PMID: 22848574; PubMed Central PMCID: PMC3407194.

31: Xie H, Zheng C. OxyR activation in Porphyromonas gingivalis in response to a hemin-limited environment. Infect Immun. 2012 Oct;80(10):3471-80. doi:10.1128/IAI.00680-12. Epub 2012 Jul 23. PubMed PMID: 22825453; PubMed Central PMCID: PMC3457554.

32: Johnson CA, Kleshchenko YY, Ikejiani AO, Udoko AN, Cardenas TC, Pratap S, Duquette MA, Lima MF, Lawler J, Villalta F, Nde PN. Thrombospondin-1 interacts with Trypanosoma cruzi surface calreticulin to enhance cellular infection. PLoS One. 2012;7(7):e40614. doi: 10.1371/journal.pone.0040614. Epub 2012 Jul 11. PubMed PMID: 22808206; PubMed Central PMCID: PMC3394756.


34: Boadi WY, Harris S, Anderson JB, Adunyah SE. Lipid peroxides and glutathione status in human progenitor mononuclear (U937) cells following exposure to low doses of nickel and copper. Drug Chem Toxicol. 2013 Apr;36(2):155-62. doi:10.3109/01480545.2012.660947. Epub 2012 May 27. PubMed PMID: 22632594.

35: Alcendor DJ, Charest AM, Zhu WQ, Vigil HE, Knobel SM. Infection and upregulation of proinflammatory cytokines in human brain vascular pericytes by human cytomegalovirus. J Neuroinflammation. 2012 May 18;9:95. doi:10.1186/1742-2094-9-95. PubMed PMID: 22607552; PubMed Central PMCID: PMC3413582.

36: Weir JM, Zakama A, Rao U. Developmental risk I: depression and the developing brain. Child Adolesc Psychiatr Clin N Am. 2012 Apr;21(2):237-59, vii. doi:10.1016/j.chc.2012.01.004. Epub 2012 Feb 17. Review. PubMed PMID: 22537725; PubMed Central PMCID: PMC3338920.

37: Shad MU, Muddasani S, Rao U. Gray matter differences between healthy and depressed adolescents: a voxel-based morphometry study. J Child Adolesc Psychopharmacol. 2012 Jun;22(3):190-7. doi: 10.1089/cap.2011.0005. Epub 2012 Apr 26. PubMed PMID: 22537357; PubMed Central PMCID: PMC3373217.

38: Bailey CK, Mittal MK, Misra S, Chaudhuri G. High motility of triple-negative breast cancer cells is due to repression of plakoglobin gene by metastasis modulator protein SLUG. J Biol Chem. 2012 Jun 1;287(23):19472-86. doi:10.1074/jbc.M112.345728. Epub 2012 Apr 11. PubMed PMID: 22496452; PubMed Central PMCID: PMC3365985.

39: Xie H, Hong J, Sharma A, Wang BY. Streptococcus cristatus ArcA interferes with Porphyromonas gingivalis pathogenicity in mice. J Periodontal Res. 2012 Oct;47(5):578-83. doi: 10.1111/j.1600-0765.2012.01469.x. Epub 2012 Mar 26. PubMed PMID: 22448761.

40: Singha UK, Hamilton V, Duncan MR, Weems E, Tripathi MK, Chaudhuri M. Protein translocase of mitochondrial inner membrane in Trypanosoma brucei. J Biol Chem. 2012 Apr 27;287(18):14480-93. doi: 10.1074/jbc.M111.322925. Epub 2012 Mar 9. PubMed PMID: 22408251; PubMed Central PMCID: PMC3340260.

41: Jules GE, Pratap S, Ramesh A, Hood DB. In utero exposure to benzo(a)pyrene predisposes offspring to cardiovascular dysfunction in later-life. Toxicology. 2012 May 16;295(1-3):56-67. doi: 10.1016/j.tox.2012.01.017. Epub 2012 Feb 21. PubMed PMID: 22374506; PubMed Central PMCID: PMC3575114.

42: Rao U. Sleep Disturbances in Pediatric Depression. Asian J Psychiatr. 2011 Dec;4(4):234-247. PubMed PMID: 22287998; PubMed Central PMCID: PMC3265574.

43: Chen X, Guo Z, Okoro EU, Zhang H, Zhou L, Lin X, Rollins AT, Yang H. Up-regulation of ATP binding cassette transporter A1 expression by very low density lipoprotein receptor and apolipoprotein E receptor 2. J Biol Chem. 2012 Feb 3;287(6):3751-9. doi: 10.1074/jbc.M111.310888. Epub 2011 Dec 14. PubMed PMID: 22170052; PubMed Central PMCID: PMC3281687.

44: Dey A, Mantri CK, Pandhare-Dash J, Liu B, Pratap S, Dash C. Downregulation of APOBEC3G by xenotropic murine leukemia-virus related virus (XMRV) in prostate cancer cells. Virol J. 2011 Dec 12;8:531. doi: 10.1186/1743-422X-8-531. PubMed PMID: 22152111; PubMed Central PMCID: PMC3268770.

45: Zheng C, Wu J, Xie H. Differential expression and adherence of Porphyromonas gingivalis FimA genotypes. Mol Oral Microbiol. 2011 Dec;26(6):388-95. doi: 10.1111/j.2041-1014.2011.00626.x. Epub 2011 Sep 8. PubMed PMID: 22053966.

46: Swant J, Goodwin JS, North A, Ali AA, Gamble-George J, Chirwa S, Khoshbouei H. α-Synuclein stimulates a dopamine transporter-dependent chloride current and modulates the activity of the transporter. J Biol Chem. 2011 Dec 23;286(51):43933-43. doi: 10.1074/jbc.M111.241232. Epub 2011 Oct 11. PubMed PMID: 21990355; PubMed Central PMCID: PMC3243541.

47: Zhao Y, Chen X, Yang H, Zhou L, Okoro EU, Guo Z. A novel function of apolipoprotein E: upregulation of ATP-binding cassette transporter A1 expression. PLoS One. 2011;6(7):e21453. doi: 10.1371/journal.pone.0021453. Epub 2011 Jul 11. PubMed PMID: 21779326; PubMed Central PMCID: PMC3136925.

48: Cooper J, Liu L, Woodruff EA, Taylor HE, Goodwin JS, D'Aquila RT, Spearman P, Hildreth JE, Dong X. Filamin A protein interacts with human immunodeficiency virus type 1 Gag protein and contributes to productive particle assembly. J Biol Chem. 2011 Aug 12;286(32):28498-510. doi: 10.1074/jbc.M111.239053. Epub 2011 Jun 24. PubMed PMID: 21705339; PubMed Central PMCID: PMC3151092.

49: Chen X, Zhao Y, Guo Z, Zhou L, Okoro EU, Yang H. Transcriptional regulation of ATP-binding cassette transporter A1 expression by a novel signaling pathway. J Biol Chem. 2011 Mar 18;286(11):8917-23. doi: 10.1074/jbc.M110.214429. Epub 2011 Jan 21. PubMed PMID: 21257755; PubMed Central PMCID: PMC3058999.

50: Kawai Y, Garduño L, Theodore M, Yang J, Arinze IJ. Acetylation-deacetylation of the transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2) regulates its transcriptional activity and nucleocytoplasmic localization. J Biol Chem. 2011 Mar 4;286(9):7629-40. doi: 10.1074/jbc.M110.208173. Epub 2010 Dec 31. PubMed PMID: 21196497; PubMed Central PMCID: PMC3045017.

51: Sledzińska A, Mielech A, Krawczyk B, Samet A, Nowicki B, Nowicki S, Jankowski Z, Kur J. Fatal sepsis in a pregnant woman with pyelonephritis caused by Escherichia coli bearing Dr and P adhesins: diagnosis based on postmortem strain genotyping. BJOG. 2011 Jan;118(2):266-9. doi: 10.1111/j.1471-0528.2010.02732.x. Epub 2010 Nov 18. PubMed PMID: 21083859.

52: Nde PN, Johnson CA, Pratap S, Cardenas TC, Kleshchenko YY, Furtak VA, Simmons KJ, Lima MF, Villalta F. Gene network analysis during early infection of human coronary artery smooth muscle cells by Trypanosoma cruzi and Its gp83 ligand. Chem Biodivers. 2010 May;7(5):1051-64. doi: 10.1002/cbdv.200900320. PubMed PMID: 20491065; PubMed Central PMCID: PMC2910116.

53: Lewis TJ, Dupont WD, Egan KM, Jones CD, Disher AC, Riddle WR, Fair AM. The "Got D'ViBE?" study: an inter-institutional project assessing vitamin D and mammographic breast density. J Health Care Poor Underserved. 2010 Feb;21(1 Suppl):17-25.doi: 10.1353/hpu.0.0238. PubMed PMID: 20173282; PubMed Central PMCID: PMC2930256.

54: Zhang D, Al-Hendy M, Richard-Davis G, Montgomery-Rice V, Sharan C, Rajaratnam V, Khurana A, Al-Hendy A. Green tea extract inhibits proliferation of uterine leiomyoma cells in vitro and in nude mice. Am J Obstet Gynecol. 2010 Mar;202(3):289.e1-9.doi: 10.1016/j.ajog.2009.10.885. Epub 2010 Jan 13. PubMed PMID: 20074693; PubMed Central PMCID: PMC2834812.

55: Cardenas TC, Johnson CA, Pratap S, Nde PN, Furtak V, Kleshchenko YY, Lima MF, Villalta F. REGULATION of the EXTRACELLULAR MATRIX INTERACTOME by Trypanosoma cruzi. Open Parasitol J. 2010;4:72-76. PubMed PMID: 21499436; PubMed Central PMCID: PMC3075921.

56: Lesser IM, Myers HF, Lin KM, Bingham Mira C, Joseph NT, Olmos NT, Schettino J, Poland RE. Ethnic differences in antidepressant response: a prospective multi-site clinical trial. Depress Anxiety. 2010;27(1):56-62. doi:10.1002/da.20619. PubMed PMID: 19960492; PubMed Central PMCID: PMC3113513.

57: Hassan MH, Salama SA, Zhang D, Arafa HM, Hamada FM, Fouad H, Walker CC, Al-Hendy A. Gene therapy targeting leiomyoma: adenovirus-mediated delivery of dominant-negative estrogen receptor gene shrinks uterine tumors in Eker rat model. Fertil Steril. 2010 Jan;93(1):239-50. doi:10.1016/j.fertnstert.2008.09.086. Epub 2009 Jan 14. PubMed PMID: 19144333; PubMed Central PMCID: PMC2812608.

REQUIREMENT: Each publication, press release, or other document about research supported by an NIH award must include an acknowledgment of NIH award support and a disclaimer such as:

"Research reported in this publication was supported by the National Institute On Minority Health And Health Disparities of the National Institutes of Health under Award Number U54 MD0007593. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health."